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Pifithrin-β

CAT: 0804-HY-16702Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-16702Size:1 Each
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Description
Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
CAS Number
60477-34-1
Product Name Alternative
PFT β; Cyclic Pifithrin-α
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pifithrin-_beta_.html
Solubility
10 mM in DMSO
Smiles
CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
Molecular Formula
C16H16N2S
Molecular Weight
268.38
References & Citations
[1]Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19 (5) :1649-57.|[2]Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88 (17-18) :774-83.|[3]Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5 (5) :390-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Citation 01
FASEB J. 2021 Feb;35 (2) :e21325.|Front Cell Dev Biol. 2020 Jul 29;8:703.|Front Immunol. 2020 Feb 20;8:75.|Front Mol Biosci. 2021 Aug 19;8:697457.|Int J Mol Med. 2021 Jul;48 (1) :122.|Int J Mol Sci. 2023 Jul 17;24 (14) :11554.|iScience. 2024 Jun 4;27 (7) :110144.|J Virol. 2025 Aug 29:e0052925.|PLoS One. 2018 Sep 20;13 (9) :e0203833. |Sci Rep. 2025 Sep 29;15 (1) :33534.|bioRxiv. 2025 March 21.|Blood Cells Mol Dis. 2024 Jan:104:102798.|Cancer Cell Int. 2023 Sep 28;23 (1) :221.|Cell Biol Int. 2025 Jul;49 (7) :852-864.|Cell Biol Toxicol. 2023 Oct;39 (5) :2011-2032.|Cell Commun Signal. 2022 Sep 5;20 (1) :96.|Heliyon. 2024 May 19.|Life Sci. 2021 Sep 1:280:119698.|mBio. 2024 Oct 30:e0213724.|Nat Commun. 2025 Feb 25;16 (1) :1774.

Chemical Information

Pifithrin-Beta

2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole is a member of imidazoles.

CAS Number60477-34-1
PubChem CID443278
IUPAC Name2-(4-methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole
Molecular FormulaC16H16N2S
Molecular Weight268.4
XLogP5
Topological Polar Surface Area45.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count19
Formal Charge0
Complexity327
SMILES
CC1=CC=C(C=C1)C2=CN3C4=C(CCCC4)SC3=N2
InChI
InChI=1S/C16H16N2S/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13/h6-10H,2-5H2,1H3
InChIKey
IMUKUMUNZJILCG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pifithrin-Beta
CAS: 60477-34-1
CID: 443278
Formula: C16H16N2S
MW: 268.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight268.4
XLogP35
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass268.10341969
Monoisotopic Mass268.10341969
Topological Polar Surface Area45.5 Ų
Heavy Atom Count19
Formal Charge0
Complexity327
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T23156-01Pifithrin-β
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MBS130140-01Pifithrin-?
2653/10Pifithrin-μ
1554-10Pifithrin-ɑ
B1083-5Pifithrin-µ
563407Pifithrin-µ
GTR19174714-01Pifithrin α

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