Pifithrin-β
CAT:
804-HY-16702
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Pifithrin-β
- CAS Number: 60477-34-1
- UNSPSC Description: Pifithrin-β (PFT β) is a potent p53 inhibitor with an IC50 of 23 μM.
- Target Antigen: MDM-2/p53
- Type: Reference compound
- Related Pathways: Apoptosis
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/pifithrin-_beta_.html
- Solubility: 10 mM in DMSO
- Smiles: CC1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
- Molecular Weight: 268.38
- References & Citations: [1]Christodoulou MS, et al. Synthesis and biological evaluation of imidazolo[2,1-b]benzothiazole derivatives, as potential p53 inhibitors. Bioorg Med Chem. 2011 Mar 1;19(5):1649-57.|[2]Fernández-Cruz ML, et al. Biological and chemical studies on aryl hydrocarbon receptor induction by the p53 inhibitor pifithrin-α and its condensation product pifithrin-β. Life Sci. 2011 Apr 25;88(17-18):774-83.|[3]Da Pozzo E, et al. p53 functional inhibitors behaving like pifithrin-β counteract the Alzheimer peptide non-β-amyloid component effects in human SH-SY5Y cells. ACS Chem Neurosci. 2014 May 21;5(5):390-9.FASEB J. 2021 Feb;35(2):e21325.|Front Cell Dev Biol. 2020 Jul 29;8:703.|Front Immunol. 2020 Feb 20;8:75.|Front Mol Biosci. 2021 Aug 19;8:697457.|Int J Mol Med. 2021 May 7.|Int J Mol Sci. 2023 Jul 17, 24(14), 11554.|iScience. 2024 Jun 04.|PLoS One. 2018 Sep 20;13(9):e0203833. |Blood Cells Mol Dis. 2024, Jan, 104, 102798.|Cancer Cell Int. 2023 Sep 28;23(1):221.|Cell Biol Toxicol. 2022 Jan 13.|Cell Commun Signal. 2022 Sep 5;20(1):96.|Heliyon. 2024 May 19.|Life Sci. 2021 Jun 7;280:119698.|mBio. 2024 Oct 30:e0213724.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported