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Pifithrin-α, p-Nitro, Cyclic

CAT: 0804-HY-123076-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123076-01Size:5 mg
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Description
Pifithrin-α, p-Nitro, Cyclic (PFN-α) is cell-permeable and active-form p53 inhibitor. Pifithrin-α, p-Nitro, Cyclic is one order magnitude more active than Pifithrin-α in protecting cortical neurons exposed to Etoposide (ED50=30 nM) . Pifithrin-α, p-Nitro, Cyclic behaves as a p53 posttranscriptional activity inhibitor. Pifithrin-α, p-Nitro, Cyclic do not prevent p53 phosphorylation on the S15 residue[1][2].
CAS Number
60477-38-5
Product Name Alternative
PFN-α
UNSPSC
12352005
Target
MDM-2/p53
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pifithrin-alpha-p-nitro-cyclic.html
Purity
99.37
Solubility
DMF : 12.5 mg/mL (ultrasonic) |DMSO : 5 mg/mL (ultrasonic)
Smiles
O=[N+]([O-])C1=CC=C(C2=CN3C(SC4=C3CCCC4)=N2)C=C1
Molecular Formula
C15H13N3O2S
Molecular Weight
299.35
References & Citations
[1]Pietrancosta N, et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J Med Chem. 2006 Jun 15;49 (12) :3645-52.|[2]Dinca EB, et al. p53 Small-molecule inhibitor enhances temozolomide cytotoxic activity against intracranial glioblastoma xenografts. Cancer Res. 2008 Dec 15;68 (24) :10034-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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