PBA-AMF

CAT: 0804-HY-159560Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-159560Size:1 Each
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Description
PBA-AMF can be activated by H2O2 to release Amonafide (AMF) (HY-10982) . PBA-AMF selectively inhibited the proliferation of breast cancer cells, while sparing non-cancerous cells. PBA-AMF inhibits tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBA-AMF can be used for research of tumors and other diseases associated with increased H2O2 levels[1].
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pba-amf.html
Smiles
O=C(C1=CC(NC(OCC2=CC=C(B(O)O)C=C2)=O)=CC3=C1C4=CC=C3)N(CCN(C)C)C4=O
Molecular Formula
C24H24BN3O6
Molecular Weight
461.27
References & Citations
[1]Yao X, et al. Amonafide-based H2O2-responsive theranostic prodrugs: Exploring the correlation between H2O2 level and anticancer efficacy. Bioorg Chem. 2024 Sep;150:107560.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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