PBA-AMF

• Description :

  PBA-AMF can be activated by H2O2 to release Amonafide (AMF) (HY-10982) . PBA-AMF selectively inhibited the proliferation of breast cancer cells, while sparing non-cancerous cells. PBA-AMF inhibits tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBA-AMF can be used for research of tumors and other diseases associated with increased H2O2 levels[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; DNA/RNA Synthesis

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pba-amf.html

• Smiles :

  O=C(C1=CC(NC(OCC2=CC=C(B(O)O)C=C2)=O)=CC3=C1C4=CC=C3)N(CCN(C)C)C4=O

• Molecular Formula :

  C24H24BN3O6

• Molecular Weight :

  461.27

• References & Citations :

  [1]Yao X, et al. Amonafide-based H2O2-responsive theranostic prodrugs: Exploring the correlation between H2O2 level and anticancer efficacy. Bioorg Chem. 2024 Sep;150:107560.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported