PBA-1105 TFA

• Target:

  AUTACs|||Autophagy

• Related Pathways:

  PROTAC|||Autophagy

• Bioactivity:

  PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. This compound selectively binds to the exposed hydrophobic regions of misfolded proteins, promoting their degradation through the autophagy (autophagy) pathway. Additionally, PBA-1105 TFA enhances the autophagic flux of Ub-bound aggregates.

• Smiles:

  C1=CC=C(C=C1)CCCC(=O)NCCOCCOCCOCCNCC2=CC(=C(C=C2)OCC3=CC=CC=C3)OCC4=CC=CC=C4.C(=O)(C(F)(F)F)O

• Molecular Formula:

  C41H49F3N2O8

• Molecular Weight:

  754.832

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C