PBE-AMF

• Target :

  Reactive Oxygen Species|||Apoptosis|||DNA/RNA Synthesis

• Related Pathways :

  DNA Damage/DNA Repair|||NF-?B|||Immunology/Inflammation|||Apoptosis|||Metabolism|||Cell Cycle/Checkpoint

• Bioactivity :

  PBE-AMF is a prodrug that activates H2O2 and exhibits anticancer activity. It impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing cell death (apoptosis), and blocking the cell cycle. PBE-AMF effectively and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 ?M) while sparing non-cancerous MCF-10A cells.

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C