PBA-1105b

• Description :

  PBA-1105b is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105b increases the autophagic flux of Ub-conjugated aggregates. PBA-1105b is a drastically longer PEG-based linker than PBA-1105[1].

• UNSPSC :

  12352005

• Target :

  Autophagy; AUTOTACs; p62

• Type :

  Reference compound

• Related Pathways :

  Autophagy; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pba-1105b.html

• Smiles :

  O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCOCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2

• Molecular Formula :

  C47H64N2O10

• Molecular Weight :

  817.02

• References & Citations :

  [1]Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2941386-60-1]