PBE-AMF

• Description :

  PBE-AMF is a prodrug that activates H2O2 with anticancer activity. PBE-AMF impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBE-AMF potently and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; DNA/RNA Synthesis; Reactive Oxygen Species (ROS)

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pbe-amf.html

• Smiles :

  O=C(C1=CC(NC(OCC2=CC=C(B3OC(C)(C)C(C)(C)O3)C=C2)=O)=CC4=C1C5=CC=C4)N(CCN(C)C)C5=O

• Molecular Formula :

  C30H34BN3O6

• Molecular Weight :

  543.42

• References & Citations :

  [1]Xueyan Yao, et al. "Amonafide-based H2O2-responsive theranostic prodrugs: Exploring the correlation between H2O2 level and anticancer efficacy." Bioorganic Chemistry (2024) : 107560.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported