PBE-AMF

CAT: 0804-HY-159515Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-159515Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PBE-AMF is a prodrug that activates H2O2 with anticancer activity. PBE-AMF impedes tumor proliferation by inhibiting DNA synthesis, reducing ATP levels, inducing apoptosis, and arresting the cell cycle. PBE-AMF potently and selectively inhibits the proliferation of MDA-MB-231 cells (IC50=6.4 μM) while sparing non-cancerous MCF-10A cells[1].
UNSPSC
12352005
Target
Apoptosis; DNA/RNA Synthesis; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pbe-amf.html
Smiles
O=C(C1=CC(NC(OCC2=CC=C(B3OC(C)(C)C(C)(C)O3)C=C2)=O)=CC4=C1C5=CC=C4)N(CCN(C)C)C5=O
Molecular Formula
C30H34BN3O6
Molecular Weight
543.42
References & Citations
[1]Xueyan Yao, et al. "Amonafide-based H2O2-responsive theranostic prodrugs: Exploring the correlation between H2O2 level and anticancer efficacy." Bioorganic Chemistry (2024) : 107560.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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