PBA-1105 (TFA)

• Description :

  PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 TFA selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 TFA increases the autophagic flux of Ub-conjugated aggregates[1].

• UNSPSC :

  12352005

• Target :

  Autophagy; AUTOTACs

• Related Pathways :

  Autophagy; PROTAC

• Field of Research :

  Cancer; Neurological Disease

• Purity :

  99.58

• Smiles :

  O=C(O)C(F)(F)F.O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2

• Molecular Formula :

  C41H49F3N2O8

• Molecular Weight :

  754.83

• References & Citations :

  [1]Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported