PBA-1105 (TFA)

CAT: 0804-HY-161743ASize: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-161743ASize:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PBA-1105 TFA is an autophagy-targeting chimera (AUTOTAC) that induces p62 self-oligomerization. PBA-1105 TFA selectively binds to exposed hydrophobic regions of misfolded proteins, facilitating their degradation via the autophagic pathway. PBA-1105 TFA increases the autophagic flux of Ub-conjugated aggregates[1].
UNSPSC
12352005
Target
Autophagy; AUTOTACs
Related Pathways
Autophagy; PROTAC
Field of Research
Cancer; Neurological Disease
Purity
99.58
Smiles
O=C(O)C(F)(F)F.O=C(CCCC1=CC=CC=C1)NCCOCCOCCOCCNCC2=CC(OCC3=CC=CC=C3)=C(OCC4=CC=CC=C4)C=C2
Molecular Formula
C41H49F3N2O8
Molecular Weight
754.83
References & Citations
[1]Chang Hoon Ji, et al. The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system. Nat Commun. 2022 Feb 16;13 (1) :904.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-161743-01PBA-1105
HY-161744PBA-1106
HY-161745PBA-1105b
HY-173300Sulfo-PBA
HY-159560PBA-AMF
HY-107711-01DQP-1105
HY-W015764-01T-1105
HY-D1383LZ-1105
HY-P990623-01MDX-1105
HY-D2853FITC-PEG-PBA (MW 2000)

Alternative Products

CatalogName
T205092-01PBA-1105 TFA
T88681-01PBA-1105
HO237237-2KPBA-PEG-PBA, 2K
T89007-01PBA-AMF
T88762-01PBA-1105b
TRC-T127135-10MGTCS 1105
MBS5757230DQP 1105
M15009-01T-1105
531764DQP-1105

Popular Products