(5Z,2E)-CU-3

(5Z,2E)-CU-3

• CAS Number: 1815598-71-0
• UNSPSC Description: (5Z,2E)-CU-3 is a potent and selective inhibitor against the α-isozyme of DGK with an IC50 value of 0.6 μM, competitively inhibits the affinity of DGKα for ATP with a Km value of 0.48 mM. (5Z,2E)-CU-3 targets the catalytic region, but not the regulatory region of DGKα. (5Z,2E)-CU-3 has antitumoral and proimmunogenic effects, enhances the apoptosis of cancer cells and the activation of T cells[1].
• Target Antigen: Apoptosis; DGK
• Type: Reference compound
• Related Pathways: Apoptosis;Metabolic Enzyme/Protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/5z-2e-cu-3.html
• Purity: 98.04
• Solubility: DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
• Smiles: O=S(C1=CC=CC=C1)(NN(C/2=O)C(SC2=C/C=C/C3=CC=CO3)=S)=O
• Molecular Weight: 392.47
• References & Citations: [1]Liu K, et al. A novel diacylglycerol kinase α-selective inhibitor, CU-3, induces cancer cell apoptosis and enhances immune response. J Lipid Res. 2016 Mar;57(3):368-79.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported