C-82

CAT: 0804-HY-112359-01Size: 1 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0804-HY-112359-01Size:1 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300[1].

CAS Number

1422253-37-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Wnt; β-catenin

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/C-82.html

Purity

99.91

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=C(N1N(C)CC(N([C@H]2CC3=CC=C(O)C=C3)[C@]1([H])[C@H](C)N(CC4=CC=CC5=C4N=CC=C5)C2=O)=O)NCC6=CC=CC=C6

Molecular Formula

C33H34N6O4

Molecular Weight

578.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP) -response Element-binding Protein (CREB) -binding Protein (CBP) /β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2 (11) :1751-8.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 2

Chemical Information

(6S,9S,9AS)-N-benzyl-6-(4-hydroxybenzyl)-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)hexahydro-2H-pyrazino[2,1-c][1,2,4]triazine-1(6H)-carboxamide

CAS Number	1422253-37-9
PubChem CID	73602848
IUPAC Name	(6S,9S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-2,9-dimethyl-4,7-dioxo-8-(quinolin-8-ylmethyl)-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazine-1-carboxamide
Molecular Formula	C33H34N6O4
Molecular Weight	578.7
XLogP	3.9
Topological Polar Surface Area	109
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Heavy Atom Count	43
Formal Charge	0
Complexity	998

SMILES

C[C@H]1[C@H]2N([C@H](C(=O)N1CC3=CC=CC4=C3N=CC=C4)CC5=CC=C(C=C5)O)C(=O)CN(N2C(=O)NCC6=CC=CC=C6)C

InChI

InChI=1S/C33H34N6O4/c1-22-31-38(29(41)21-36(2)39(31)33(43)35-19-24-8-4-3-5-9-24)28(18-23-13-15-27(40)16-14-23)32(42)37(22)20-26-11-6-10-25-12-7-17-34-30(25)26/h3-17,22,28,31,40H,18-21H2,1-2H3,(H,35,43)/t22-,28-,31-/m0/s1

InChIKey

KLGHKOORFHZFGO-AZXNYEMZSA-N

Chemical Structure

2D Structure

CAS: 1422253-37-9

CID: 73602848

Formula: C33H34N6O4

MW: 578.7

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	578.7
XLogP3	3.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	6
Exact Mass	578.26415359
Monoisotopic Mass	578.26415359
Topological Polar Surface Area	109 Å²
Heavy Atom Count	43
Formal Charge	0
Complexity	998
Isotope Atom Count	0
Defined Atom Stereocenter Count	3
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-168462	α-Glucosidase-IN-82
HY-136241-01	OT-82
HY-169922	HDAC-IN-82
HY-162902	ALK5-IN-82
HY-149401	EGFR-IN-82
HY-170938	AChE-IN-82
HY-U00028	T 82
HY-163265	HSD17B13-IN-82
HY-175464	NLRP3-IN-82
HY-136499-01	DI-82

Alternative Products

Catalog	Name
MBS3614730-01	C-82
1216152	Mini strip +71/+82°C
CCP2225-01	C-Reactive Protein (77-82)
RM-C061882-01	Cefuroxime Impurity 82; Deacetoxycephalosporin C
BE170832-01	Ex 82
T204291-01	α-Glucosidase-IN-82
T200604-01	ALK5-IN-82
207115	OT-82
GTR19249265-01	AChE-IN-82
GTR19264529-01	NLRP3-IN-82

C-82

Chemical Information

Related Products

Alternative Products

Popular Products