C-82

• Description:

  C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Wnt; β-catenin

• Type:

  Reference compound

• Related Pathways:

  Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/C-82.html

• Purity:

  99.91

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles:

  O=C (N1N (C) CC (N ([C@H]2CC3=CC=C (O) C=C3) [C@]1 ([H]) [C@H] (C) N (CC4=CC=CC5=C4N=CC=C5) C2=O) =O) NCC6=CC=CC=C6

• Molecular Formula:

  C33H34N6O4

• Molecular Weight:

  578.66

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP) -response Element-binding Protein (CREB) -binding Protein (CBP) /β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2 (11) :1751-8.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  1422253-37-9