C-82

• Description :

  C-82 is a second-generation specific CBP/β-catenin antagonist, which inhibits the binding between β-catenin and CBP and increases the binding between β-catenin and p300[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Wnt; β-catenin

• Type :

  Reference compound

• Related Pathways :

  Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/C-82.html

• Purity :

  99.91

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic)

• Smiles :

  O=C(N1N(C)CC(N([C@H]2CC3=CC=C(O)C=C3)[C@]1([H])[C@H](C)N(CC4=CC=CC5=C4N=CC=C5)C2=O)=O)NCC6=CC=CC=C6

• Molecular Formula :

  C33H34N6O4

• Molecular Weight :

  578.66

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Osawa Y, et al. Inhibition of Cyclic Adenosine Monophosphate (cAMP) -response Element-binding Protein (CREB) -binding Protein (CBP) /β-Catenin Reduces Liver Fibrosis in Mice. EBioMedicine. 2015 Oct 8;2 (11) :1751-8.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [1422253-37-9]