PROTAC SMARCA2 degrader-17

• CAS Number:

  2568276-43-5

• UNSPSC Description:

  PROTAC SMARCA2 degrader-17 (compound I-290) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 90 after 24 h of treatment[1].

• Target Antigen:

  PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-degrader-17.html

• Smiles:

  OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC=C(C6CCN(C7CCC(C8=CC(N(C)C(N9C%10CCC(NC%10=O)=O)=O)=C9C=C8)CC7)CC6)C=N5)C3)=C(N)N=N2

• Molecular Weight:

  797.95

• References & Citations:

  [1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported