PROTAC SMARCA2 degrader-16

PROTAC SMARCA2 degrader-16

• CAS Number: 2568276-37-7
• UNSPSC Description: PROTAC SMARCA2 degrader-16 (compound I-278) is a PROTAC degrader targeting SMARCA2; it degrades SMARCA2 proteins in A549 cells with an DC50 90 after 24 h of treatment[1].
• Target Antigen: PROTACs
• Type: Reference compound
• Related Pathways: PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-degrader-16.html
• Smiles: OC1=CC=CC=C1C2=CC(N3CC4CCC(N4C5=NC(C6CCN(CCCC7=CC(N(C)C(N8C9CCC(NC9=O)=O)=O)=C8C=C7)CC6)=NC=C5)C3)=C(N)N=N2
• Molecular Weight: 757.88
• References & Citations: [1]Preparation of heterocyclic compounds as SMARCA degraders and uses thereof. World Intellectual Property Organization, WO2020251971 A1 2020-12-17.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported