PROTAC SMARCA2/4-degrader-17

PROTAC SMARCA2/4-degrader-17

• CAS Number: 2568276-88-8
• UNSPSC Description: PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades SMARCA2 in A549 with DC50 SMARCA4 in MV411 with DC50 [1]
• Target Antigen: Epigenetic Reader Domain; PROTACs
• Type: Reference compound
• Related Pathways: Epigenetics;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-smarca2-4-degrader-17.html
• Smiles: NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6=C(C=C(C=C6)CC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)C)C=N5)C(CC4)C3
• Molecular Weight: 936.13
• References & Citations: [1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported