PROTAC SMARCA2/4-degrader-17

• CAS Number:

  2568276-88-8

• UNSPSC Description:

  PROTAC SMARCA2/4-degrader-17 (Compound I-345) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-17 degrades SMARCA2 in A549 with DC50 SMARCA4 in MV411 with DC50 [1]

• Target Antigen:

  Epigenetic Reader Domain; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-smarca2-4-degrader-17.html

• Smiles:

  NC1=C(C=C(C2=C(C=CC=C2)O)N=N1)N3CC4N(C5=NC=C(C6=C(C=C(C=C6)CC(N[C@@H](C(C)(C)C)C(N7[C@@H](C[C@H](C7)O)C(NCC8=CC=C(C9=C(N=CS9)C)C=C8)=O)=O)=O)C)C=N5)C(CC4)C3

• Molecular Weight:

  936.13

• References & Citations:

  [1]Ji N, et al., Smarca degraders and uses thereof. US20230072658A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported