U-0521

• Description :

  U-0521 is the inhibitor of the catechol-O-methyltransferase (COMT) . U-0521 has the potential for the research of Parkinson's disease[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302, H312, H332

• Target :

  COMT

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease; Neuronal Signaling

• Applications :

  Neuroscience-Neurodegeneration

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/u-0521.html

• Purity :

  98.67

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  CC(C(C1=CC=C(C(O)=C1)O)=O)C

• Molecular Formula :

  C10H12O3

• Molecular Weight :

  180.20

• Precautions :

  H302, H312, H332

• References & Citations :

  [1]Reches A, et al. Effect of 3',4'-dihydroxy-2-methyl-propriophenone (U-0521) on catechol-O-methyltransferase activity and on DOPA accumulation in rat red blood cells and corpus striatum. Biochem Pharmacol. 1982;31 (21) :3415-3418.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [5466-89-7]