U-74389G

• Description :

  U-74389G (PNU74389G meleate) is an antioxidant, can inhibit lipid peroxidation reactions. U-74389G can protect against ischemia-reperfusion injury and be widely used in animal models of ischemic injury and hypertension. U-74389G shows anti-inflammatory activity[1][2][3].

• CAS Number :

  [153190-29-5]

• Product Name Alternative :

  PNU74389G (meleate)

• UNSPSC :

  12352005

• Target :

  Others

• Type :

  Reference compound

• Related Pathways :

  Others

• Field of Research :

  Others; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/u-74389g.html

• Purity :

  98.64

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  OC(/C=C\C(O)=O)=O.C[C@@]12[C@](CC[C@@H]2C(CN3CCN(C4=NC(N5CCCC5)=NC(N6CCCC6)=C4)CC3)=O)([H])[C@@]7([H])C([C@@]8(C(CC7)=CC(C=C8)=O)C)=CC1

• Molecular Formula :

  C41H54N6O6

• Molecular Weight :

  726.90

• References & Citations :

  [1]A M Perna, et al. Protection of rat heart from ischaemia-reperfusion injury by the 21-aminosteroid U-74389G. Pharmacol Res. 1996 Jul-Aug;34 (1-2) :25-31.|[2]Georgios Antonios Margonis, et al. Effectiveness of sildenafil and U-74389G in a rat model of colitis. J Surg Res. 2015 Feb;193 (2) :667-74.|[3]D Altavilla, et al. The lazaroid, U-74389G, inhibits inducible nitric oxide synthase activity, reverses vascular failure and protects against endotoxin shock. Eur J Pharmacol. 1999 Mar 12;369 (1) :49-55.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, sealed storage, away from moisture)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported