U-101017

• UNSPSC Description:

  U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects.

• Target Antigen:

  GABA Receptor

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/U-101017.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=C2N(C=N1)C3=C(C=C(Cl)C=C3)C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)=C2)OC(C)(C)C

• Molecular Weight:

  442.94

• References & Citations:

  [1]Hall ED, et al. Comparative neuroprotective properties of the benzodiazepine receptor full agonist diazepam and the partial agonist PNU-101017 in the gerbil forebrain ischemia model. Brain Res. 1998 Jul 6;798(1-2):325-9.|[2]Sethy VH, et al. The novel anxiolytic U-101017: in vitro and ex vivo binding profile and effect on cerebellar cGMP. Pharmacol Biochem Behav. 1997 Oct;58(2):609-13.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  170568-47-5