U-101017

• Description :

  U-101017 is a partial agonist of benzodiazepine receptor and GABAA receptor, with anxiolytic effects.

• Product Name Alternative :

  PNU 101017

• UNSPSC :

  12352005

• Target :

  GABA Receptor

• Type :

  Reference compound

• Related Pathways :

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/U-101017.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=C2N(C=N1)C3=C(C=C(Cl)C=C3)C(C(N4C[C@@H](C)N[C@@H](C)C4)=O)=C2)OC(C)(C)C

• Molecular Formula :

  C23H27ClN4O3

• Molecular Weight :

  442.94

• References & Citations :

  [1]Hall ED, et al. Comparative neuroprotective properties of the benzodiazepine receptor full agonist diazepam and the partial agonist PNU-101017 in the gerbil forebrain ischemia model. Brain Res. 1998 Jul 6;798 (1-2) :325-9.|[2]Sethy VH, et al. The novel anxiolytic U-101017: in vitro and ex vivo binding profile and effect on cerebellar cGMP. Pharmacol Biochem Behav. 1997 Oct;58 (2) :609-13.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [170568-47-5]