U 92032

• Description:

  U 92032 is a T-type Ca2+ channel antagonist. U 92032 inhibits Na+ channels. U-92032 inhibits thalamic oscillations. U 92032 can be used in the research of neurological diseases[1].

• UNSPSC:

  12352005

• Target:

  Calcium Channel; Sodium Channel

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  O=C1C (=CC (=CC=C1CN2CCN (CC2) C (C3=CC=C (F) C=C3) C4=CC=C (F) C=C4) C (C) C) NCCO

• Molecular Formula:

  C30H35F2N3O2

• Molecular Weight:

  507.63

• References & Citations:

  [1]Porcello DM, et al. Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between I (T) and slow intrathalamic rhythms. J Neurophysiol. 2003 Jan;89 (1) :177-85.|[2]Avery RB, et al. Ca2+ channel antagonist U-92032 inhibits both T-type Ca2+ channels and Na+ channels in hippocampal CA1 pyramidal neurons. J Neurophysiol. 1997 Feb;77 (2) :1023-8.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  142223-92-5