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ARS-2102

CAT: 0804-HY-152248Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-152248Size:1 Each
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Description
ARS-2102 is a potent covalent KRAS G12C inhibitor for use in cancer research[1].
CAS Number
2098509-21-6
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ars-2102.html
Solubility
10 mM in DMSO
Smiles
FC1=C(C2=C(C=CC=C2O)F)C(Cl)=CC3=C1N=C(N4CC(C4)N(C)C)N=C3N5[C@H](CN([C@@H](C5)C)C(C=C)=O)C
Molecular Formula
C28H31ClF2N6O2
Molecular Weight
557.03
References & Citations
[1]Xiaogen Yang, et al. Hindered Biaryl Bond Construction and Subsequent Diastereomeric Crystallization to Produce an Atropisomeric Covalent KRASG12C Inhibitor ARS-2102.Org. Process Res. Dev. 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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