ARS-1323-alkyne

• UNSPSC Description:

  ARS-1323-alkyne, a switch-II pocket (S-IIP) inhibitor, is a conformational specific chemical reporter of KRASG12C nucleotide state in living cells[1]. ARS-1323-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

• Target Antigen:

  Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ars-1323-alkyne.html

• Purity:

  99.59

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(C=C)N1CCN(C2=NC(NCCC(N(C)CC#C)=O)=NC3=C(F)C(C4=C(O)C=CC=C4F)=C(Cl)C=C23)CC1

• Molecular Weight:

  569.00

• References & Citations:

  [1]Lou K,et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12(583). pii: eaaw9450.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Clinical Information:

  No Development Reported

• CAS Number:

  2436544-27-1