ARS-1323-alkyne

CAT: 0804-HY-128522-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-128522-01Size:1 mg
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Description
ARS-1323-alkyne is a covalent inhibitor probe that covalently binds to the Switch-II pocket (S-IIP) of the KRAS G12C mutant protein. ARS-1323-alkyne visualizes the covalent modification of KRAS G12C and quantitatively measures the binding efficiency of the inhibitor to the target. ARS-1323-alkyne can be used to validate the target occupancy of KRAS G12C inhibitors and the synergistic mechanism of combination therapy, providing tool support for the development of combination treatment strategies[1].
CAS Number
[2436544-27-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ars-1323-alkyne.html
Purity
99.59
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(C=C)N1CCN(C2=NC(NCCC(N(C)CC#C)=O)=NC3=C(F)C(C4=C(O)C=CC=C4F)=C(Cl)C=C23)CC1
Molecular Formula
C28H27ClF2N6O3
Molecular Weight
569.00
Precautions
H302, H315, H319, H335
References & Citations
[1]Lou K, et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12 (583) . pii: eaaw9450.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

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