ARS-1323-alkyne

• Description:

  ARS-1323-alkyne is a covalent inhibitor probe that covalently binds to the Switch-II pocket (S-IIP) of the KRAS G12C mutant protein. ARS-1323-alkyne visualizes the covalent modification of KRAS G12C and quantitatively measures the binding efficiency of the inhibitor to the target. ARS-1323-alkyne can be used to validate the target occupancy of KRAS G12C inhibitors and the synergistic mechanism of combination therapy, providing tool support for the development of combination treatment strategies[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ars-1323-alkyne.html

• Purity:

  99.59

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  O=C(C=C)N1CCN(C2=NC(NCCC(N(C)CC#C)=O)=NC3=C(F)C(C4=C(O)C=CC=C4F)=C(Cl)C=C23)CC1

• Molecular Formula:

  C28H27ClF2N6O3

• Molecular Weight:

  569.00

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Lou K, et al. KRASG12C inhibition produces a driver-limited state revealing collateral dependencies. Sci Signal. 2019 May 28;12 (583) . pii: eaaw9450.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, stored under nitrogen)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  K-Ras

• CAS Number:

  [2436544-27-1]