ARS-853

• Description:

  ARS-853 is a cell-active, selective, covalent KRAS G12C inhibitor with an IC50 of 2.5 μM. ARS-853 inhibits mutant KRAS-driven signaling by binding to the GDP-bound oncoprotein and preventing activation[1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Apoptosis; Ras

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; GPCR/G Protein; MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ARS-853.html

• Purity:

  98.39

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  ClC1=C (C2 (C) CC2) C=C (NCC (N3CCN (C4CN (C (C=C) =O) C4) CC3) =O) C (O) =C1

• Molecular Formula:

  C22H29ClN4O3

• Molecular Weight:

  432.94

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Lito P, et al. Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism. Science. 2016 Feb 5;351 (6273) :604-8.|[2]Patricelli MP, et al. Selective Inhibition of Oncogenic KRAS Output with Small Molecules Targeting the Inactive State. Cancer Discov. 2016 Mar;6 (3) :316-29.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  K-Ras

• CAS Number:

  1629268-00-3