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IGF2R Antibody / M6PR

CAT: 0800-R31304Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-R31304Size:100 µg
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Description
Insulin-like growth factor 2 receptor, also called Mannose 6 phosphate receptor (M6PR), is a protein that in humans is encoded by the IGF2R gene. This gene is mapped to 6q25.3. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
P11717
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
An amino acid sequence from the C-terminus of human Mannose 6 Phosphate Receptor/Insulin like Growth Factor 2 Receptor (TKLVSFHDDSDEDLLHI) was used as the immunogen for this M6PR / IGF2R antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, FACS
Purity
Antigen affinity
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the IGF2R antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This IGF2R antibody is available for research use only.
Storage Conditions
After reconstitution, the IGF2R antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
The stated application concentrations are suggested starting amounts. Titration of the IGF2R antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Image Legend
Flow cytometry testing of fixed and permeabilized human HepG2 cells with IGF2R antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= IGF2R antibody.

UniProtKB · P11717

Cation-independent mannose-6-phosphate receptor

MPRI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11717
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IGF2R
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CI Man-6-P receptor, CI-MPR, M6PR
EC number
—
Processing
Precursor
Secondary accessions
Q7Z7G9, Q96PT5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinLipoproteinMethylationPalmitatePhosphoprotein

Cellular component

EndosomeGolgi apparatusMembrane

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

Biological process

Transport

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