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M6PR Antibody / IGF2R

CAT: 0800-RQ4264Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ4264Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Insulin-like growth factor 2 receptor, also called IGF2R, I-MPR and M6PR (mannose 6-phosphate receptor) is a protein that in humans is encoded by the IGF2R gene. This gene is mapped to 6q25.3. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence (FFPE) : 5 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL
UniProt
P11717
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
A recombinant human protein corresponding to amino acids F424-R529 was used as the immunogen for the M6PR antibody.
Clonality
Polyclonal
Isotype
IgG
Applications
WB, IHC-P, IF, FACS, ELISA
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the M6PR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This M6PR antibody is available for research use only.
Storage Conditions
After reconstitution, the M6PR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the M6PR antibody should be determined by the researcher.
Location
Cytoplasm (lysosome membrane)
Image Legend
IHC testing of FFPE human lung cancer tissue with M6PR antibody. Required HIER: steam section in pH8 EDTA buffer for 20 min and allow to cool prior to staining.

UniProtKB · P11717

Cation-independent mannose-6-phosphate receptor

MPRI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11717
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IGF2R
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CI Man-6-P receptor, CI-MPR, M6PR
EC number
—
Processing
Precursor
Secondary accessions
Q7Z7G9, Q96PT5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinLipoproteinMethylationPalmitatePhosphoprotein

Cellular component

EndosomeGolgi apparatusMembrane

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

Biological process

Transport
Product Datasheet
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