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IGF1R Antibody

CAT: 0800-F50633-0.4MLSize: 0.4 mLDry Ice: NoHazardous: No
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CAT#:0800-F50633-0.4MLSize:0.4 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The IGF1 receptor binds insulin-like growth factor with a high affinity and plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. The protein possess tyrosine kinase activity.
CAS Number
9007-83-4
Specifications
Western blot: 1:1000, IHC (Paraffin) : 1:50-1:100
UniProt
P08069
Host
Rabbit
Reactivity
Human
Immunogen
A portion of amino acids 19-51 from the human protein was used as the immunogen for this IGF1R antibody.
Clonality
Polyclonal
Isotype
Ig
Applications
WB, IHC, ELISA
Purity
Purified
Format
Purified
Buffer
In 1X PBS, pH 7.4, with 0.09% sodium azide
Reconstitution
Aliquot the IGF1R antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This IGF1R antibody is available for research use only.
Storage Conditions
Aliquot the IGF1R antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
In 1X PBS, pH 7.4, with 0.09% sodium azide
Applications Notes
Titration of the IGF1R antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Prediction Reactivity
Mouse, Rat
Image Legend
IHC analysis of FFPE human breast carcinoma tissue stained with the IGF1R antibody

UniProtKB · P08069

Insulin-like growth factor 1 receptor

IGF1R_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08069
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IGF1R
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.10.1
Processing
Precursor
Secondary accessions
B1B5Y2, Q14CV2, Q9UCC0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell membraneMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Disease

Disease variant

Biological process

Host-virus interaction

Molecular function

KinaseReceptorTransferaseTyrosine-protein kinase

Domain

RepeatSignalTransmembraneTransmembrane helix

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