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M6PR Antibody / IGF2R

CAT: 0800-RQ6533Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0800-RQ6533Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Insulin-like growth factor 2 receptor, also called IGF2R or I-MPR is a protein that in humans is encoded by the IGF2R gene. This gene is mapped to 6q25.3. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL
UniProt
P11717
Host
Mouse
Reactivity
Human
Immunogen
An E. coli-derived human protein (amino acids F424-R529) was used as the immunogen for the M6PR antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
6G2
Applications
WB, IHC-P
Purity
Affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
After reconstitution, the M6PR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.
Limitations
This M6PR antibody is available for research use only.
Storage Conditions
After reconstitution, the M6PR antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the M6PR antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human gastric cancer tissue with M6PR antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.

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