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M6PR Antibody / IGF2R

CAT: 0800-RQ5375Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0800-RQ5375Size:100 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. [RefSeq]
CAS Number
9000-83-3
Specifications
Western blot: 1:1000-1:2000, Immunohistochemistry (FFPE) : 1:50-1:200
UniProt
P11717
Host
Rabbit
Reactivity
Human
Immunogen
A synthetic peptide specific to human M6PR / IGF2R was used as the immunogen for the M6PR antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
DIC-9
Type
Recombinant
Applications
IHC-P, WB
Purity
Affinity purified
Format
Purified
Buffer
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA
Reconstitution
Store the M6PR antibody at -20oC.
Limitations
This M6PR antibody is available for research use only.
Storage Conditions
Store the M6PR antibody at -20°C.
Formulation
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5 mg/mL BSA
Applications Notes
Optimal dilution of the M6PR antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
Western blot testing of human Jurkat cell lysate with M6PR antibody. Predicted molecular weight ~274 kDa.

UniProtKB · P11717

Cation-independent mannose-6-phosphate receptor

MPRI_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P11717
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IGF2R
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CI Man-6-P receptor, CI-MPR, M6PR
EC number
—
Processing
Precursor
Secondary accessions
Q7Z7G9, Q96PT5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationDisulfide bondGlycoproteinLipoproteinMethylationPalmitatePhosphoprotein

Cellular component

EndosomeGolgi apparatusMembrane

Molecular function

Receptor

Domain

RepeatSignalTransmembraneTransmembrane helix

Biological process

Transport
Product Datasheet
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