PROTAC NAMPT Degrader-1

• UNSPSC Description:

  PROTAC NAMPT Degrader-1 is a potent PROTAC targeting NAMPT with aDC50 value of 217 nM. PROTAC NAMPT Degrader-1 has anti-proliferative activity with an IC50 value of 0.12μM against A2780 cells. (Structure Note: PINK, NAMPT activator (HY-163445); Blue, VHL ligand (HY-163440); Black, linker)[1].

• Target Antigen:

  NAMPT; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-nampt-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NCC1=CC=NC=C1)NC2=CC=C(C=C2)S(=O)(N3CCN(CC3)C(C4=CC=C(C=C4)/N=N/C5=C(N(N=C5C)CCCCC(N[C@@H](C(C)(C)C)C(N6[C@@H](C[C@H](C6)O)C(N[C@H](C7=CC=C(C=C7)C8=C(N=CS8)C)C)=O)=O)=O)C)=O)=O

• Molecular Weight:

  1128.37

• References & Citations:

  [1]Cheng J, et al. Photoswitchable PROTACs for Reversible and Spatiotemporal Regulation of NAMPT and NAD. Angew Chem Int Ed Engl. 2024 Mar 18;63(12):e202315997.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported