PROTAC Vif degrader-1

• UNSPSC Description:

  PROTAC Vif degrader-1 (Compound L15) is a Vif PROTAC degrader. PROTAC Vif degrader-1 has antiviral activity against HIV-1 (EC50: 33.35 μM against HIV-1IIIB). Blue: CRBN ligand (HY-10984); Black: linker; Pink: HIV-1 inhibitor(HY-163852)[1].

• Target Antigen:

  HIV; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/protac-vif-degrader-1.html

• Smiles:

  COC1=CC=C(C=C1NC(C2=C(C=CC=C2SC3=CC=C(C=C3)[N+]([O-])=O)N)=O)OCC(NCCOCCOCCNC4=C5C(N(C(C5=CC=C4)=O)C6CCC(NC6=O)=O)=O)=O

• Molecular Weight:

  855.87

• References & Citations:

  [1]Luo D, et al. Discovery of L15 as a novel Vif PROTAC degrader with antiviral activity against HIV-1. Bioorg Med Chem Lett. 2024 Jul 10;111:129880.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported