PROTAC Hemagglutinin Degrader-1

• UNSPSC Description:

  PROTAC Hemagglutinin Degrader-1 (Compound V3) is a potent PROTAC influenza hemagglutinin (HA) degrader with a median degradation concentration of 1.44 μM. PROTAC Hemagglutinin Degrader-1 shows broad-spectrum anti-influenza virus activity[1].

• Target Antigen:

  Influenza Virus; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Anti-infection;PROTAC

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/protac-hemagglutinin-degrader-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)[C@H](C(C)(C)C)NC(CCOCCOCCOCCNC([C@]45[C@](CC(C)(CC5)C)([H])C6=CC[C@@]([C@@]7([C@@](C(C)([C@H](CC7)O)C)([H])CC8)C)([H])[C@]8(C)[C@@]6(CC4)C)=O)=O

• Molecular Weight:

  1072.48

• References & Citations:

  [1]Li H, et al. Discovery of Pentacyclic Triterpenoid PROTACs as a Class of Effective Hemagglutinin Protein Degraders. J Med Chem. 2022 May 26;65(10):7154-7169.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3031330-66-9