PROTAC sEH-degrader-1

• UNSPSC Description:

  sEH-degrader-1 (Compound 8) serves as an inhibitor for sEH, with IC50 values of 3.8 nM and 210 nM against hsEH and msEH respectively. sEH-degrader-1 can effectively degrade sEH in mouse liver and brown adipose tissue (Red: UC-1728 (HY-114266), black: linker (HY-W248248), Blue: Thalidomide-5-piperazine (HY-W834174))[1].

• Target Antigen:

  Epoxide Hydrolase; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;PROTAC

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/protac-seh-degrader-1.html

• Smiles:

  O=C(CCCCCCCCNC(C1=CC=C(O[C@@H]2CC[C@@H](NC(NC3=CC=C(OC(F)(F)F)C=C3)=O)CC2)C=C1)=O)N4CCC(CN(CC5)CCN5C6=CC7=C(C(N(C7=O)C(C(N8)=O)CCC8=O)=O)C=C6)CC4

• Molecular Weight:

  1015.13

• References & Citations:

  [1]Nakane K, et al. In vivo-Active Soluble Epoxide Hydrolase-targeting PROTACs with Improved Potency and Stability[J]. bioRxiv, 2024: 2024.07. 23.604814.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported