NAMPT degrader-1

NAMPT degrader-1

• CAS Number: 3011778-39-2
• UNSPSC Description: NAMPT degrader-1 (Compound A3), an autophagosome-tethering compound (ATTEC), is an nicotinamide phosphoribosyltransferase (NAMPT) degrader with an IC50 of 0.023 μM. NAMPT degrader-1 significantly induces the degradation of NAMPT through the autophagy-lysosomal pathway and shows excellent cellular antitumor potency[1].
• Target Antigen: ATTECs; Autophagy; NAMPT
• Type: Reference compound
• Related Pathways: Autophagy;Metabolic Enzyme/Protease;PROTAC
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/nampt-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1N(C([C@@H](C(C)C)N(CCCNC(CCCCCCCCN2CCN(S(C3=CC=C(NC(NCC4=CC=CN=C4)=S)C=C3)(=O)=O)CC2)=O)C(C5=CC=C(C=C5)C)=O)=NC6=CC(Cl)=CC=C61)CC7=CC=CC=C7
• Molecular Weight: 1046.78
• References & Citations: [1]Dong G, et al. Ispinesib as an Effective Warhead for the Design of Autophagosome-Tethering Chimeras: Discovery of Potent Degraders of Nicotinamide Phosphoribosyltransferase (NAMPT). J Med Chem. 2022 Jun 9;65(11):7619-7628.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported