PROTAC PIN1 degrader-1

• UNSPSC Description:

  PROTAC PIN1 degrader-1 (compound D4) is a PROTAC targeting PIN1, with a DC50=1.8 nM. The GI50 of PROTAC PIN1 degrader-1 to MDA-MB-468 is >30 μM. PROTAC PIN1 degrader-1 is composed of target protein ligand PIN1 ligand-1 (HY-168038) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part), and PROTAC linker (black part)[1].

• Target Antigen:

  PIN1; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR;PROTAC

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-pin1-degrader-1.html

• Smiles:

  CC1=CC=CN=C1C2(CC2)C(NC(CC(N=N3)=CN3C(C=C4)=CC=C4C(C=C5)=CC=C5C#N)C(NC(CC6)CCN6CCCCCOC7=CC=CC(C8=O)=C7C(N8C(CC9)C(NC9=O)=O)=O)=O)=O

• Molecular Weight:

  917.02

• References & Citations:

  [1]Liu C, et al. Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs. J Med Chem. 2024 Sep 12;67(17):15780-15795.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3038591-59-9