PROTAC PIN1 degrader-1

PROTAC PIN1 degrader-1

• CAS Number: 3038591-59-9
• UNSPSC Description: PROTAC PIN1 degrader-1 (compound D4) is a PROTAC targeting PIN1, with a DC50=1.8 nM. The GI50 of PROTAC PIN1 degrader-1 to MDA-MB-468 is >30 μM. PROTAC PIN1 degrader-1 is composed of target protein ligand PIN1 ligand-1 (HY-168038) (red part), E3 ligase ligand Thalidomide (HY-14658) (blue part), and PROTAC linker (black part)[1].
• Target Antigen: PIN1; PROTACs
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR;PROTAC
• Applications: Cancer-Kinase/protease
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/protac-pin1-degrader-1.html
• Smiles: CC1=CC=CN=C1C2(CC2)C(NC(CC(N=N3)=CN3C(C=C4)=CC=C4C(C=C5)=CC=C5C#N)C(NC(CC6)CCN6CCCCCOC7=CC=CC(C8=O)=C7C(N8C(CC9)C(NC9=O)=O)=O)=O)=O
• Molecular Weight: 917.02
• References & Citations: [1]Liu C, et al. Re-Evaluating PIN1 as a Therapeutic Target in Oncology Using Neutral Inhibitors and PROTACs. J Med Chem. 2024 Sep 12;67(17):15780-15795.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported