PROTAC FLT3/CDKs degrader-1

• UNSPSC Description:

  PROTAC FLT3/CDKs degrader-1 (Compound C3) is a degrader for cyclin-dependent kinases (DC50 is 18.73 nM for CDK2) and the FMS-like tyrosine kinase 3 (FLT3). PROTAC FLT3/CDKs degrader-1 induces differentation of HL-60 (72.77% differentation at 6.25 nM), inhibits proliferation of AML cells, with IC50s of 2.9-37 nM. PROTAC FLT3/CDKs degrader-1 is potential for ameliorating acute myeloid leukemia. (Pink: ligand for target protein FLT3/CDKs ligand-1 (HY-161709); Black: linker (HY-W012935); Black: ligand for E3 ligase Thalidomide 5-fluoride (HY-W087383))[1]

• Target Antigen:

  CDK; FLT3; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;PROTAC;Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-flt3-cdks-degrader-1.html

• Smiles:

  O=C(NC1=O)CCC1N(C2=O)C(C3=C2C=CC(N(CC4)CCC4CN(CC5)CCN5CC6=CC=C(NC(C7=NNC=C7NC8=C9C(NC=C9)=NC=N8)=O)C=C6)=C3)=O

• Molecular Weight:

  770.84

• References & Citations:

  [1]Barik S. Expression and biochemical properties of a protein serine/threonine phosphatase encoded by bacteriophage lambda. Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10633-7.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported