PROTAC MPS1 degrader 1

• UNSPSC Description:

  PROTAC MPS1 degrader 1 (Compound 19) is a potent degrader of monopolar spindle 1 (Mps1, TTK), AURKA and AURKB, with DC50s of 17.7, 108.7 and 570.3 nM, respectively. PROTAC MPS1 degrader 1 can be used for the research of acute myeloid leukemia. (Pink: ligand for target protein (HY-168542); Black: linker (HY-W141926); Blue: ligand for E3 ligase (HY-10984)[1].

• Target Antigen:

  Aurora Kinase; Mps1; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage;Cytoskeleton;Epigenetics;PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-mps1-degrader-1.html

• Smiles:

  O=C(NCC(N1CCN(C2=CC=C(NC3=NC(NC4CCCCC4)=C5N=CNC5=N3)C=C2)CC1)=O)CCCC(NC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O

• Molecular Weight:

  818.88

• References & Citations:

  [1]Sflakidou E, et, al. Development of 2-Aminoadenine-Based Proteolysis-Targeting Chimeras (PROTACs) as Novel Potent Degraders of Monopolar Spindle 1 and Aurora Kinases. ACS Pharmacol. Transl. Sci. 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported