PROTAC YAP degrader-1

PROTAC YAP degrader-1

• UNSPSC Description: PROTAC YAP degrader-1 (compound YZ-6) is a PROTAC targeting YAP and also inhibits the nuclear localization of YAP. PROTAC YAP degrader-1 is composed of PROTAC target protein ligand NSC682769 (HY-168017) (red part) and E3 ubiquitin ligase ligand + Linker conjugate (R,S,R)-AHPC-PEG2-C2-boc (HY-168019) (blue+black part), in which the PROTAC Linker used is Acid-PEG2-C2-Boc (HY-140480) and the target protein ligand activity control is Demethyl-NSC682769 (HY-168018)[1].
• Target Antigen: PROTACs; YAP
• Type: Reference compound
• Related Pathways: PROTAC;Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/protac-yap-degrader-1.html
• Smiles: O=C(N[C@H](C)C1=CC=C(C=C1)C2=C(N=CS2)C)[C@@H]3N(C[C@H](C3)O)C([C@@H](C(C)(C)C)NC(CCOCCOCCOC4=CC=C(C=C4OC)C5=C(C(C6=CC=CC=C6N7)=NC(C8=CC=CC=C8)=C5)CC7=O)=O)=O
• Molecular Weight: 995.19
• References & Citations: [1]Zhou C, et al. Exploring Degradation of Intrinsically Disordered Protein Yes-Associated Protein Induced by Proteolysis TArgeting Chimeras. J Med Chem. 2024 Sep 12;67(17):15168-15198.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported