PROTAC FLT3/CDK9 degrader-1

PROTAC FLT3/CDK9 degrader-1

• UNSPSC Description: PROTAC FLT3/CDK9 degrader-1 is a potent FLT3 and CDK9 dual PROTAC degrader. PROTAC FLT3/CDK9 degrader-1 induces apoptosis and effective degradation of target proteins FLT3 and CDK9. PROTAC FLT3/CDK9 degrader-1 has the potential for the research of FLT3-ITD mutated AML[1].
• Target Antigen: Apoptosis; CDK; FLT3; PROTACs
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage;PROTAC;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/protac-flt3-cdk9-degrader-1.html
• Solubility: 10 mM in DMSO
• Smiles: NC(CC1)CCC1NC2=NC(NC(C=C3)=CC=C3N(CC4)CCN4CCOCCOCCNC(CNC5=CC=CC(C(N6C7C(NC(CC7)=O)=O)=O)=C5C6=O)=O)=C8C(N(C9CCCC9)C=N8)=N2
• Molecular Weight: 920.07
• References & Citations: [1]Řezníčková E, et al. Modulation of FLT3-ITD and CDK9 in acute myeloid leukaemia cells by novel proteolysis targeting chimera (PROTAC). Eur J Med Chem. 2022 Dec 5;243:114792.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported