JAK2-IN-10

• Description :

  JAK2-IN-10 (compound 5) is a potent JAK2 V617F inhibitor with an IC50 value of ≤10 nM[1].

• UNSPSC :

  12352005

• Target :

  JAK

• Type :

  Isotope-Labeled Compounds

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Purity :

  97.97

• Smiles :

  O=C(N1C)N([C@@H]2CC[C@@](NC(C3CC3)=O)(C)CC2)C4=C1C=NC5=C4C(C6=CC(C=NN7C([2H])([2H])[2H])=C7C=C6)=C(C8=CN(CC)N=C8F)N5

• Molecular Formula :

  C33H33D3FN9O2

• Molecular Weight :

  612.71

• References & Citations :

  [1]Seoyoung Cho, et al. Tricyclic urea compounds as jak2 v617f inhibitors. WO2024086273A1. 2024.05.25.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Isotope-Labeled Compounds

• Clinical Information :

  No Development Reported

• Isoform :

  JAK2

• CAS Number :

  [3035735-18-0]