JAK2-IN-9

• Description :

  JAK2-IN-9 (Compound A8) is a selective JAK2 inhibitor (IC50: 5 nM) . JAK2-IN-9 inhibits the phosphorylation of JAK2, STAT3, and STAT5. JAK2-IN-9 has metabolic stabilities. JAK2-IN-9 induces apoptosis. JAK2-IN-9 can be used for research of myeloproliferative neoplasms (MPNs) [1].

• CAS Number :

  [2568842-26-0]

• UNSPSC :

  12352005

• Target :

  JAK

• Type :

  Reference compound

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/jak2-in-9.html

• Solubility :

  10 mM in DMSO

• Smiles :

  C=CS(=O)(NCC1=CC=C(NC2=NC=C(C)C(C3=CN(C(C)C)N=C3)=N2)C=C1)=O

• Molecular Formula :

  C20H24N6O2S

• Molecular Weight :

  412.51

• References & Citations :

  [1]Tian Y, et al Discovery of N- (4- (Aminomethyl) phenyl) -5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors. ACS Med Chem Lett. 2023 Aug 1;14 (8) :1113-1121.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  JAK2