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JAK2-IN-9

CAT: 0804-HY-155746Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155746Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JAK2-IN-9 (Compound A8) is a selective JAK2 inhibitor (IC50: 5 nM) . JAK2-IN-9 inhibits the phosphorylation of JAK2, STAT3, and STAT5. JAK2-IN-9 has metabolic stabilities. JAK2-IN-9 induces apoptosis. JAK2-IN-9 can be used for research of myeloproliferative neoplasms (MPNs) [1].
CAS Number
2568842-26-0
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/jak2-in-9.html
Solubility
10 mM in DMSO
Smiles
C=CS(=O)(NCC1=CC=C(NC2=NC=C(C)C(C3=CN(C(C)C)N=C3)=N2)C=C1)=O
Molecular Formula
C20H24N6O2S
Molecular Weight
412.51
References & Citations
[1]Tian Y, et al Discovery of N- (4- (Aminomethyl) phenyl) -5-methylpyrimidin-2-amine Derivatives as Potent and Selective JAK2 Inhibitors. ACS Med Chem Lett. 2023 Aug 1;14 (8) :1113-1121.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2

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