JAK2-IN-12

• Description :

  JAK2-IN-12 (compound 23) is a JAK2 inhibitor with a pIC50 of 8.2. JAK2-IN-12 can be used for study of myelofibrosi[1].

• UNSPSC :

  12352005

• Target :

  JAK

• Related Pathways :

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research :

  Cancer

• Smiles :

  CC1=C(C2=CC(COC/C=C/COCC3=C(OCCN4CCCC4)C=CC5=C3)=CC=C2)N=C(N5)N=C1

• Molecular Formula :

  C29H34N4O3

• Molecular Weight :

  486.61

• References & Citations :

  [1]Braz NF, et al. Application of Free Energy Perturbation (FEP) Methodology for Predicting the Binding Affinity of Macrocyclic JAK2 Inhibitor Analogues of Pacritinib. ACS Med Chem Lett. 2025 May 21;16 (6) :1066-1072.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported