JAK2-IN-12

• Description:

  JAK2-IN-12 (compound 23) is a JAK2 inhibitor with a pIC50 of 8.2. JAK2-IN-12 can be used for study of myelofibrosi[1].

• UNSPSC:

  12352005

• Target:

  JAK

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  CC1=C(C2=CC(COC/C=C/COCC3=C(OCCN4CCCC4)C=CC5=C3)=CC=C2)N=C(N5)N=C1

• Molecular Formula:

  C29H34N4O3

• Molecular Weight:

  486.61

• References & Citations:

  [1]Braz NF, et al. Application of Free Energy Perturbation (FEP) Methodology for Predicting the Binding Affinity of Macrocyclic JAK2 Inhibitor Analogues of Pacritinib. ACS Med Chem Lett. 2025 May 21;16 (6) :1066-1072.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported