JAK2-IN-18

• Description:

  JAK2-IN-18 (Compound example1) is a selective JAK2 inhibitor. JAK2-IN-18 can inhibit JAK-STAT signaling and shows an IC50 of [1].

• UNSPSC:

  12352005

• Target:

  JAK; STAT

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cardiovascular Disease

• Smiles:

  COC(C(NC1=CC(NC(C2CC2)=O)=NN3C1=NC=C3)=CC=C4)=C4C5=CC(C6(CC6)C7)=C(C=C5)C(N7CC8=CC=CC(C(N(C)C)=O)=N8)=O

• Molecular Formula:

  C37H36N8O4

• Molecular Weight:

  656.73

• References & Citations:

  [1]Xiaowei Wu, et al. Jak2 inhibitors and their use as pharmaceuticals. WO2025240835A2. 2025-11-20

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JAK2; STAT5

• CAS Number:

  3108318-77-7