JAK2-IN-17

• Description:

  JAK2-IN-17 (compound 20) is a potent JAK2 allosteric inhibitor. JAK2-IN-17 inhibits full-length JAK2 and JAK2 V617F with IC50s of 160 and 130 nM, respectively. JAK2-IN-17 covalently modifies Lys677 in the pseudokinase domain[1].

• UNSPSC:

  12352005

• Target:

  JAK

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer

• Smiles:

  NS(C1=CC=C(NC2=NN(C(C3=CC=CC(OS(F)(=O)=O)=C3)=O)C(N)=N2)C=C1)(=O)=O

• Molecular Formula:

  C15H13FN6O6S2

• Molecular Weight:

  456.43

• References & Citations:

  [1]Primi MC, et al. Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118274.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JAK2