JAK2-IN-17

CAT: 0804-HY-179428Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179428Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
JAK2-IN-17 (compound 20) is a potent JAK2 allosteric inhibitor. JAK2-IN-17 inhibits full-length JAK2 and JAK2 V617F with IC50s of 160 and 130 nM, respectively. JAK2-IN-17 covalently modifies Lys677 in the pseudokinase domain[1].
UNSPSC
12352005
Target
JAK
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
NS(C1=CC=C(NC2=NN(C(C3=CC=CC(OS(F)(=O)=O)=C3)=O)C(N)=N2)C=C1)(=O)=O
Molecular Formula
C15H13FN6O6S2
Molecular Weight
456.43
References & Citations
[1]Primi MC, et al. Allosteric inhibition of JAK2 with lysine-reactive compounds that bind the pseudokinase domain. Eur J Med Chem. 2026 Jan 15;302 (Pt 1) :118274.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
JAK2

Related Products

CatalogName
HY-161684-01JAK2-IN-10
HY-155746JAK2-IN-9
HY-179687JAK2-IN-18
HY-176479JAK2-IN-12
HY-16641JAK1-IN-17
HY-173601JAK3-IN-17
HY-178936JAK2-IN-15
HY-175684JAK2-IN-14
HY-174988JAK2-IN-13
HY-137756-01JAK2-IN-6

Alternative Products

CatalogName
MBS8533783-01JAK2

Popular Products