JAK2-IN-11

JAK2-IN-11

• CAS Number: 3057053-17-2
• UNSPSC Description: JAK2-IN-11 (Example 6) is a JAK2 kinase inhibitor with IC50 ≤10 nM against JH2 BIND WT/V617F. JAK2-IN-11 has antitumor activity[1].
• Target Antigen: JAK
• Type: Isotope-Labeled Compounds
• Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Field of Research: Cancer
• Smiles: O=C1N([C@H]2C[C@@H](CC2)NC(OC)=O)C3=CC(NC4=NC5=C(C=CC=C5C(F)(F)F)C(C(N6CCC(CC6)C#N)=O)=C4)=NC=C3N1C([2H])([2H])[2H]
• Molecular Weight: 639.64
• References & Citations: [1]Xin Li, et al. Bicyclic ureas as kinase inhibitors. WO2024191996A1.2024-09-19.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported