JAK2-IN-15

• Description:

  JAK2-IN-15 is an orally active, potent, selective JAK2 inhibitor (IC50 = 1.17 nM) . JAK2-IN-15 can inhibit the AK2-STAT signaling pathway. JAK2-IN-15 significantly improves key pathological indicators such as hematocrit and splenomegaly in an Epoetin beta (HY-114134) (rhEPO) -induced mouse model. JAK2-IN-15 can be used for the study of Polycythemia Vera (PV) [1].

• Target:

  JAK; STAT

• Related Pathways:

  Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt

• Field of Research:

  Cancer; Inflammation/Immunology

• Smiles:

  CC1=C2N=C(NC3=CC=C(C(COC/C=C/COCC4=CC=CC(N2)=C4)=C3)OCCN5CCOCC5)N=C1

• Molecular Formula:

  C29H35N5O4

• Molecular Weight:

  517.62

• References & Citations:

  [1]Hu F, et al. Exploring the macrocyclic chemical space for heuristic drug design with deep learning models. Commun Chem. 2025 Oct 7;8 (1) :299.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  JAK2

• CAS Number:

  [3094174-82-7]