U-90042

CAT: 0804-HY-103496Size: 1 EachDry Ice: NoHazardous: No

CAT#:0804-HY-103496Size:1 Each

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Description

U-90042 is a gamma-aminobutyric acidA receptor agonist of α1, α3 and α6 subtypes with Ki values of 7.8 nM, 9.5 nM and 11.0 nM, respectively. U-90042 suppresses locomotor activity and impairs rotarod performance in mice. U-90042 produces sedation and ataxia and prolongs sleeping time in mice, rats and monkeys. U-90042 can be used as a sedative and hypnotic agent[1].

CAS Number

[134516-99-7]

UNSPSC

12352005

Target

GABA Receptor

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/u-90042.html

Smiles

ClC1=CC(C2=NCCN2C3=C(C4=NOC(C5CC5)=N4)N=CN63)=C6C=C1

Molecular Formula

C17H13ClN6O

Molecular Weight

352.78

References & Citations

[1]Tang AH, et al. U-90042, a sedative/hypnotic compound that interacts differentially with the GABAA receptor subtypes. J Pharmacol Exp Ther. 1995 Nov;275 (2) :761-7.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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