Complement Factor D / CFD Recombinant Protein

CAT: 0223-11-335Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0223-11-335Size:0.1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Complement factor D (CFD) is also known as Adipsin, C3 convertase activator, Properdin factor D (PFD), which contains one peptidase S1 domain and belongs to the peptidase S1 family. CFD / Adipsin cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. CFD / Adipsin is a serine protease that stimulates glucose transport for triglyceride accumulation in fats cells and inhibits lipolysis. Defects in CFD / Adipsin are the cause of complement factor D deficiency which predisposes to invasive meningococcal disease.
CAS Number
9000-83-3
NCBI Gene ID
1675
Swiss Prot
P00746
Accession Number
NP_001919.2
Tag
Fc Tag
Type
Recombinant Proteins
Source
HEK293 cells
Purity
>95% as determined by SDS-PAGE.
Buffer
Tris with Glycine, Arginine and NaCl, pH7.5
Shipping Conditions
Room Temp
Storage Conditions
Lyophilized Protein should be stored at -20˚ C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20˚ C or -70˚ C. Avoid repeated freeze-thaw cycles.
Calculated Molecular Weight
50.8 kDa
Applications Notes
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 50.8 kDa. The protein migrates as 53 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
NCBI Official Name
Complement factor D
NCBI Organism
Homo sapiens
Background Reference 01
White R.T., et al., 1992, J. Biol. Chem. 267:9210-9213.
Background Reference 02
Johnson D.M.A., et al., 1984, FEBS Lett. 166:347-351.
Background Reference 03
Sprong T., et al., 2006, Blood 107:4865-4870.
Other Product Names
CFD, Adipsin, PFD, DF, Complement factor D
Tested Applications
WB
Species
Human
Physical Properties
Lyophilized

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