Complement factor H Recombinant Protein

• Background:

  Complement Factor H (CFH) is a secreted protein which is a member of the regulators of complement activation family and is a complement control protein. It is expressed by the liver and secreted in plasma. Its principal function is to regulate the Alternative Pathway of the complement system, ensuring that the complement system is directed towards pathogens or other dangerous material and does not damage host tissue. Factor H regulates complement activation on self cells and surfaces by possessing both cofactor activity for the Factor I mediated C3b cleavage, and decay accelerating activity against the alternative pathway C3-convertase, C3bBb. Factor H exerts its protective action on self cells and self surfaces but not on the surfaces of bacteria or viruses, because it binds to glycosaminoglycans (GAGs) that are generally present on host cells but not, normally, on pathogen surfaces.

• NCBI Gene ID:

  3075

• Swiss Prot:

  P08603-2

• Accession Number:

  P08603-2

• Tag:

  C-6 His tag

• Type:

  Recombinant Proteins

• Source:

  Human Cells

• Field of Research:

  Cancer

• Buffer:

  Supplied as a 0.2 um filtered solution of PBS,20%Glycerol,5% Trehalose, pH7.4. It is not recommended to reconstitute to a concentration less than 100 ug/ml.

• Shipping Conditions:

  Dry Ice

• Calculated Molecular Weight:

  50 kD

• Applications Notes:

  This recombinant protein can be used for biological assays. For research use only.

• NCBI Official Name:

  Complement factor H

• NCBI Organism:

  Homo sapiens

• Other Product Names:

  Complement factor H, CFH

• Species:

  Human

• Physical Properties:

  Liquid

• CAS Number:

  9000-83-3