Pomalidomide-C2-NH2

• Description :

  Pomalidomide-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a PEG linker used in PROTAC technology.

• CAS Number :

  [1957235-66-3]

• Product Name Alternative :

  Cereblon Ligand-Linker Conjugates 15

• UNSPSC :

  12352005

• Hazard Statement :

  H315, H319, H335

• Target :

  E3 Ligase Ligand-Linker Conjugates

• Type :

  Reference compound

• Related Pathways :

  PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/e3-ligase-ligand-17.html

• Purity :

  99.32

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(NC1=O)CCC1N(C2=O)C(C3=C2C(NCCN)=CC=C3)=O

• Molecular Formula :

  C15H16N4O4

• Molecular Weight :

  316.31

• Precautions :

  H315, H319, H335

• References & Citations :

  [1]Shibata N, et al. Development of Protein Degradation Inducers of Androgen Receptor by Conjugation of Androgen Receptor Ligands and Inhibitor of Apoptosis Protein Ligands. J Med Chem. 2018 Jan 25;61 (2) :543-575.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, protect from light)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Cereblon