Products for Research Use Only
RegisterLogin

Pomalidomide-PEG3-C2-NH2 (TFA)

CAT: 0804-HY-128716A-01Size: 50 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-128716A-01Size:50 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Pomalidomide-PEG3-C2-NH2 TFA (Cereblon Ligand-Linker Conjugates 5 (TFA) ) is a synthetic E3 ligase ligand-linker conjugate comprising a Pomalidomide -based cereblon ligand and a 3-unit PEG linker. Pomalidomide-PEG3-C2-NH2 TFA can be used for the synthesis of PROTACs[1].
CAS Number
2414913-97-4
Product Name Alternative
Cereblon Ligand-Linker Conjugates 5 (TFA) ; E3 ligase Ligand-Linker Conjugates 30 (TFA)
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugates-30-tfa.html
Purity
99.0
Solubility
DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic) |H2O : 16.67 mg/mL (ultrasonic)
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCN)=O.OC(C(F)(F)F)=O
Molecular Formula
C23H29F3N4O9
Molecular Weight
562.49
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62 (2) :448-466.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

Chemical Information

Pomalidomide-PEG3-C2-NH2 (TFA)
CAS Number2414913-97-4
PubChem CID138911350
IUPAC Name4-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethylamino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione;2,2,2-trifluoroacetic acid
Molecular FormulaC23H29F3N4O9
Molecular Weight562.5
Topological Polar Surface Area187
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count13
Heavy Atom Count39
Formal Charge0
Complexity772
SMILES
C1CC(=O)NC(=O)C1N2C(=O)C3=C(C2=O)C(=CC=C3)NCCOCCOCCOCCN.C(=O)(C(F)(F)F)O
InChI
InChI=1S/C21H28N4O7.C2HF3O2/c22-6-8-30-10-12-32-13-11-31-9-7-23-15-3-1-2-14-18(15)21(29)25(20(14)28)16-4-5-17(26)24-19(16)27;3-2(4,5)1(6)7/h1-3,16,23H,4-13,22H2,(H,24,26,27);(H,6,7)
InChIKey
ZPYDGLGSAUHERM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Pomalidomide-PEG3-C2-NH2 (TFA)
CAS: 2414913-97-4
CID: 138911350
Formula: C23H29F3N4O9
MW: 562.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight562.5
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count14
Rotatable Bond Count13
Exact Mass562.18866300
Monoisotopic Mass562.18866300
Topological Polar Surface Area187 Ų
Heavy Atom Count39
Formal Charge0
Complexity772
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Related Products

CatalogName
HY-128716-01Pomalidomide-PEG3-C2-NH2
HY-112599APomalidomide-PEG4-C2-NH2 (TFA)
HY-130521-01Pomalidomide-amido-PEG3-C2-NH2
HY-128716B-01Pomalidomide-PEG3-C2-NH2 (hydrochloride)
HY-112599-01Pomalidomide-PEG4-C2-NH2
HY-128846-01Pomalidomide-C2-NH2
HY-133817APomalidomide-amino-PEG3-NH2
HY-148662Pomalidomide-PEG5-C2-NH2 (hydrochloride)
HY-112599B-01Pomalidomide-PEG4-C2-NH2 (hydrochloride)
HY-103611-01Thalidomide-O-amido-PEG3-C2-NH2 (TFA)

Alternative Products

CatalogName
MBS5770749Pomalidomide-PEG3-C2-NH2 (TFA)
GTR19276488-01Pomalidomide-PEG4-C2-NH2 TFA
MBS3613544-01Thalidomide-O-amido-PEG3-C2-NH2 TFA
MBS3844583-01Thalidomide-O-amido-PEG3-C2-NH2 (TFA)
A20133-50Thalidomide-O-amido-PEG3-C2-NH2 (TFA) 50mg
A20133-5Thalidomide-O-amido-PEG3-C2-NH2 (TFA) 5mg
A20133-500Thalidomide-O-amido-PEG3-C2-NH2 (TFA) 500mg
A20133-10Thalidomide-O-amido-PEG3-C2-NH2 (TFA) 10mg
A20133-100Thalidomide-O-amido-PEG3-C2-NH2 (TFA) 100mg
A20133-25Thalidomide-O-amido-PEG3-C2-NH2 (TFA) 25mg

Popular Products