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Pomalidomide-PEG3-C2-NH2

CAT: 0804-HY-128716-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-128716-01Size:1 g
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Description
Pomalidomide-PEG3-C2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology.
CAS Number
2093416-31-8
Product Name Alternative
Cereblon Ligand-Linker Conjugates 5; E3 ligase Ligand-Linker Conjugates 30
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugates-30.html
Solubility
10 mM in DMSO
Smiles
O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCN)=O
Molecular Formula
C21H28N4O7
Molecular Weight
448.47
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression. J Med Chem. 2019 Jan 24;62 (2) :448-466.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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MBS3615554-01Pomalidomide-PEG3-C2-NH2
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A19141-100Pomalidomide-PEG3-C2-NH2 100mg
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A19141-200Pomalidomide-PEG3-C2-NH2 200mg
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