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BMS-192364

CAT: 0804-HY-114865-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-114865-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-192364 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux[1][2][3].
CAS Number
202822-21-7
Product Name Alternative
1,25-Dihydroxyvitamin D3
UNSPSC
12352005
Target
Calcium Channel; RGS Protein
Type
Reference compound
Related Pathways
GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/bms-192364.html
Purity
99.01
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1N(C2=CC(Cl)=CC=C2O)NC(C3=CC=C(C(F)(F)F)C=C3)=N1
Molecular Formula
C15H9ClF3N3O2
Molecular Weight
355.70
References & Citations
[1]Kevin Fitzgerald, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2 (4) :e57.|[2]Maciej Salaga, et al. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Bioessays. 2016 Apr;38 (4) :344-54.|[3]David P Basile, et al. A GAP in our knowledge of vascular signaling in acute kidney injury. Kidney Int. 2011 Aug;80 (3) :233-5.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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